When you see this sign at the intersections of Whitehead and Fleming streets near the Monroe County Courthouse, you have reached the “end of the road” of the longest north-south interstate in the United States: U.S. Route 1. It begins in northern Maine and travels 2,369 miles along the eastern seaboard until arriving in Key West. Hopefully this iconic sign is there when you arrive. It is one of the most popular road markers in the U.S. to steal. A local t-shirt shop even trademarked the image.