If you are interested in a large, modern luxury hotel while in Cartagena, you will find several in the Bocagrande district. If you prefer charming accommodations, then focus on Old Town. There are many boutiques tucked into historic colonial buildings. A good example is the Casa Pombo, named after the family who lived here beginning in the 16th century. The current mansion was built in 1804. The hotel’s inner courtyard is graced with lovely blooming plants leading to its few, spacious apartments.